In vivo pharmacokinetic study of remdesivir dry powder for inhalation in hamsters

In vivo pharmacokinetic study of remdesivir dry powder for inhalation in hamsters

Remdesivir dry powder for inhalation was previously developed using thin film freezing (TFF). A single-dose 24-h pharmacokinetic study in hamsters demonstrated that pulmonary delivery of TFF remdesivir can achieve plasma remdesivir and GS-441524 levels higher than the reported EC50s of both remdesiv...

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Bibliographic Details
Main Authors: Sawittree Sahakijpijarn, Chaeho Moon, Zachary N. Warnken, Esther Y. Maier, Jennie E. DeVore, Dale J. Christensen, John J. Koleng, Robert O. Williams, III
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
SARS-CoV-2
COVID-19
Remdesivir
Dry powder for inhalation
Thin film freezing
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156721000025

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http://www.sciencedirect.com/science/article/pii/S2590156721000025

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