Investigating Core Signaling Pathways of Hepatitis B Virus Pathogenesis for Biomarkers Identification and Drug Discovery via Systems Biology and Deep Learning Method

Investigating Core Signaling Pathways of Hepatitis B Virus Pathogenesis for Biomarkers Identification and Drug Discovery via Systems Biology and Deep Learning Method

Hepatitis B Virus (HBV) infection is a major cause of morbidity and mortality worldwide. However, poor understanding of its pathogenesis often gives rise to intractable immune escape and prognosis recurrence. Thus, a valid systematic approach based on big data mining and genome-wide RNA-seq data is...

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Bibliographic Details
Main Authors: Shen Chang, Lily Hui-Ching Wang, Bor-Sen Chen
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Biomedicines
Subjects:
hepatitis B virus infection
pathogenesis
host/pathogen interspecies genetic and epigenetic network (HPI-GEN)
systems medicine discovery
drug-target interaction (DTI) model
deep learning
Online Access:https://www.mdpi.com/2227-9059/8/9/320

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https://www.mdpi.com/2227-9059/8/9/320

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