3D Spheroids Derived from Human Lipedema ASCs Demonstrated Similar Adipogenic Differentiation Potential and ECM Remodeling to Non-Lipedema ASCs In Vitro

3D Spheroids Derived from Human Lipedema ASCs Demonstrated Similar Adipogenic Differentiation Potential and ECM Remodeling to Non-Lipedema ASCs In Vitro

The growth and differentiation of adipose tissue-derived stem cells (ASCs) is stimulated and regulated by the adipose tissue (AT) microenvironment. In lipedema, both inflammation and hypoxia influence the expansion and differentiation of ASCs, resulting in hypertrophic adipocytes and deposition of c...

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Bibliographic Details
Main Authors: Sara Al-Ghadban, India A. Pursell, Zaidmara T. Diaz, Karen L. Herbst, Bruce A. Bunnell
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
adipose tissue-derived stem cells (ASCs)
lipedema
spheroids
adipogenic differentiation
ECM markers
inflammation
Online Access:https://www.mdpi.com/1422-0067/21/21/8350

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https://www.mdpi.com/1422-0067/21/21/8350

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