Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo.

Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo.

Loss of barrier integrity precedes the development of pathologies such as metastasis, inflammatory disorders, and blood-retinal barrier breakdown present in neovascular age-related macular degeneration. Rap1 GTPase is involved in regulating both endothelial and epithelial cell junctions; the specifi...

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Bibliographic Details
Main Authors: Erika S Wittchen, Eiichi Nishimura, Manabu McCloskey, Haibo Wang, Lawrence A Quilliam, Magdalena Chrzanowska-Wodnicka, M Elizabeth Hartnett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3769400?pdf=render

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http://europepmc.org/articles/PMC3769400?pdf=render

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