Identification of genetic modifiers of murine hepatic β-glucocerebrosidase activity

Identification of genetic modifiers of murine hepatic β-glucocerebrosidase activity

The acid β-glucocerebrosidase (GCase) enzyme cleaves glucosylceramide into glucose and ceramide. Loss of function variants in the gene encoding for GCase can lead to Gaucher disease and Parkinson's disease. Therapeutic strategies aimed at increasing GCase activity by targeting a modulating fact...

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Bibliographic Details
Main Authors: Anyelo Durán, Boris Rebolledo-Jaramillo, Valeria Olguin, Marcelo Rojas-Herrera, Macarena Las Heras, Juan F. Calderón, Silvana Zanlungo, David A. Priestman, Frances M. Platt, Andrés D. Klein
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
Systems genetics
Modifier genes
β-glucocerebrosidase
Inbred strains
Gaucher disease
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821002004

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http://www.sciencedirect.com/science/article/pii/S2405580821002004

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