Anti-HIV-1 response elicited in rabbits by anti-idiotype monoclonal antibodies mimicking the CD4-binding site.

Anti-HIV-1 response elicited in rabbits by anti-idiotype monoclonal antibodies mimicking the CD4-binding site.

Antibodies against conserved epitopes on HIV-1 envelope glycoproteins (Env), such as the gp120 CD4-binding site (CD4bs), could contribute to protection against HIV-1. Env-based immunogens inducing such a response could be a major component of future anti-HIV-1 strategies. In this proof-of-concept st...

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Bibliographic Details
Main Authors: Roberto Burioni, Nicasio Mancini, Donata De Marco, Nicola Clementi, Mario Perotti, Giovanni Nitti, Monica Sassi, Filippo Canducci, Krisha Shvela, Patrizia Bagnarelli, John R Mascola, Massimo Clementi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2565497?pdf=render

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http://europepmc.org/articles/PMC2565497?pdf=render

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