IGF-1C domain-modified hydrogel enhances therapeutic potential of mesenchymal stem cells for hindlimb ischemia

IGF-1C domain-modified hydrogel enhances therapeutic potential of mesenchymal stem cells for hindlimb ischemia

Abstract Background Poor cell engraftment and survival after transplantation limited the application of stem cell therapy. Synthetic biomaterials could provide an artificial microenvironment for stem cells, thereby improve cell survival and enhance the therapeutic efficiency of stem cells. Methods W...

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Bibliographic Details
Main Authors: Nianhuan Zhao, Zhiwei Yue, Jian Cui, Yong Yao, Xianghe Song, Bangping Cui, Xin Qi, Zhibo Han, Zhong-Chao Han, Zhikun Guo, Zuo-Xiang He, Zongjin Li
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells (MSCs)
C domain peptide of insulin-like growth factor-1 (IGF-1C)
Hydrogel
Hindlimb ischemia
Angiogenesis
Molecular imaging
Online Access:http://link.springer.com/article/10.1186/s13287-019-1230-0

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http://link.springer.com/article/10.1186/s13287-019-1230-0

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