DNA Polymerases at the Eukaryotic Replication Fork Thirty Years after: Connection to Cancer

DNA Polymerases at the Eukaryotic Replication Fork Thirty Years after: Connection to Cancer

Recent studies on tumor genomes revealed that mutations in genes of replicative DNA polymerases cause a predisposition for cancer by increasing genome instability. The past 10 years have uncovered exciting details about the structure and function of replicative DNA polymerases and the replication fo...

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Bibliographic Details
Main Authors: Youri I. Pavlov, Anna S. Zhuk, Elena I. Stepchenkova
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
DNA polymerases
proofreading exonucleases
replication fidelity
mutation rates
cancer predisposition
Online Access:https://www.mdpi.com/2072-6694/12/12/3489

Internet

https://www.mdpi.com/2072-6694/12/12/3489

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