HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice

HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice

Abstract Background Type 2 diabetes mellitus (T2DM) is a chronic metabolic dysfunction characterized by progressive insulin resistance and hyperglycaemia. Increased blood-brain barrier (BBB) permeability is a critical neurovascular complication of T2DM that adversely affects the central nervous syst...

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Bibliographic Details
Main Authors: Qiuchen Zhao, Fang Zhang, Zhanyang Yu, Shuzhen Guo, Ning Liu, Yinghua Jiang, Eng H. Lo, Yun Xu, Xiaoying Wang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Histone deacetylase 3 (HDAC3)
Diabetes
Blood-brain barrier (BBB)
Hyperglycemia
Interleukin 1 beta (IL1β)
Online Access:http://link.springer.com/article/10.1186/s12974-019-1495-3

Internet

http://link.springer.com/article/10.1186/s12974-019-1495-3

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