Oritavancin polymethylmethacrylate (PMMA)—compressive strength testing and in vitro elution

Abstract Background Polymethylmethacrylate (PMMA) is used for local antimicrobial delivery in orthopedic infection. Oritavancin is a long half-life lipoglycopeptide with broad activity against Gram-positive bacteria. Herein, we addressed if 7.5% w/w oritavancin mixed into PMMA affects PMMA strength...

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Bibliographic Details
Main Authors: Suzannah M. Schmidt-Malan, Kerryl E. Greenwood-Quaintance, Lawrence J. Berglund, Jayawant Mandrekar, Robin Patel
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13018-019-1080-6