Solubility Enhancement of Domperidone by Solvent Change In situ Micronization Technique

Solubility Enhancement of Domperidone by Solvent Change In situ Micronization Technique

Background: Domperidone (DOM), a dopamine receptor antagonist, is used as antiemetic for the treatment of gastroparesis, vomiting, and nausea. The low water solubility of DOM leads to a low dissolution rate and variable bioavailability. The aim of this study was to enhance the solubility of DOM by t...

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Bibliographic Details
Main Authors: Saeede Enteshari, Jaleh Varshosaz
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Advanced Biomedical Research
Subjects:
Differential scanning calorimetry
domperidone
Fourier transform infrared spectroscopy
in situ micronization
microcrystals
scanning electron microscopy
solvent change method
water solubility
dissolution rate
X-ray diffraction
Online Access:http://www.advbiores.net/article.asp?issn=2277-9175;year=2018;volume=7;issue=1;spage=109;epage=109;aulast=Enteshari

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http://www.advbiores.net/article.asp?issn=2277-9175;year=2018;volume=7;issue=1;spage=109;epage=109;aulast=Enteshari

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