HERC Ubiquitin Ligases in Cancer

HERC Ubiquitin Ligases in Cancer

HERC proteins are ubiquitin E3 ligases of the HECT family. The HERC subfamily is composed of six members classified by size into large (HERC1 and HERC2) and small (HERC3–HERC6). HERC family ubiquitin ligases regulate important cellular processes, such as neurodevelopment, DNA damage response, cell p...

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Bibliographic Details
Main Authors: Joan Sala-Gaston, Arturo Martinez-Martinez, Leonardo Pedrazza, L. Francisco Lorenzo-Martín, Rubén Caloto, Xosé R. Bustelo, Francesc Ventura, Jose Luis Rosa
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
HECT
E3
oncogene
tumor suppressor
genome stability
p53
Online Access:https://www.mdpi.com/2072-6694/12/6/1653

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