miR-505 Downregulates 6-Phosphofructo-2-Kinase/ Fructose-2,6-Biphosphatase 4 to Promote Cell Death in Glioblastoma

miR-505 Downregulates 6-Phosphofructo-2-Kinase/ Fructose-2,6-Biphosphatase 4 to Promote Cell Death in Glioblastoma

Aim: The glycolytic enzyme, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), mediates shifts in glycolytic flux and is important for glioblastoma cell survival. This study aimed to identify micro-RNAs that alter PFKFB4 expression to regulate glioblastoma cell survival. Methods: Weste...

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Bibliographic Details
Main Authors: Esther H Chung, Hongwei Yang, Hongyan Xing, Rona S Carroll, Mark D Johnson
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Cancer Translational Medicine
Subjects:
6-phosphofructo-2-kinase/fructose-2
6-biphosphatase 4
cancer stem cells
glioblastoma multiforme
miR-505
reactive oxygen species
Online Access:http://www.cancertm.com/article.asp?issn=2395-3977;year=2015;volume=1;issue=5;spage=158;epage=165;aulast=Chung

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http://www.cancertm.com/article.asp?issn=2395-3977;year=2015;volume=1;issue=5;spage=158;epage=165;aulast=Chung

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