Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes

Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes

Abstract Background Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation and is one of the most common chronic degenerative joint diseases that causes pain and disability in adults. Urolithin A (UA) has been widely reported for its anti-inflammatory propert...

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Bibliographic Details
Main Authors: Sheng-long Ding, Zhi-ying Pang, Xue-mei Chen, Zheng Li, Xin-xin Liu, Qi-lin Zhai, Jun-ming Huang, Zhi-yong Ruan
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Inflammation
Subjects:
Urolithin a
Osteoarthritis
NF-κB
MAPK
Inflammation
Online Access:http://link.springer.com/article/10.1186/s12950-020-00242-8

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http://link.springer.com/article/10.1186/s12950-020-00242-8

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