Transcriptional Reactivation of the FMR1 Gene. A Possible Approach to the Treatment of the Fragile X Syndrome

Transcriptional Reactivation of the FMR1 Gene. A Possible Approach to the Treatment of the Fragile X Syndrome

Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability, caused by CGG expansion over 200 repeats (full mutation, FM) at the 5′ untranslated region (UTR) of the fragile X mental retardation 1 (FMR1) gene and subsequent DNA methylation of the promoter region, accompanie...

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Bibliographic Details
Main Authors: Elisabetta Tabolacci, Federica Palumbo, Veronica Nobile, Giovanni Neri
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Genes
Subjects:
Fragile X syndrome
FMR1 gene
epigenetic therapy
DNA methylation
histone modifications
drug treatments
Online Access:http://www.mdpi.com/2073-4425/7/8/49

Internet

http://www.mdpi.com/2073-4425/7/8/49

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