Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels

Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels

Abstract Background Increased levels of the pathogenic amyloid β-peptide (Aβ), released from its precursor by the transmembrane protease γ-secretase, are found in Alzheimer disease (AD) brains. Interestingly, monoamine oxidase B (MAO-B) activity is also increased in AD brain, but its role in AD path...

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Bibliographic Details
Main Authors: Sophia Schedin-Weiss, Mitsuhiro Inoue, Lenka Hromadkova, Yasuhiro Teranishi, Natsuko Goto Yamamoto, Birgitta Wiehager, Nenad Bogdanovic, Bengt Winblad, Anna Sandebring-Matton, Susanne Frykman, Lars O. Tjernberg
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer disease pathogenesis
Alzheimer disease
Amyloid β-peptide
Monoamine oxidase B
Intraneuronal amyloid β-peptide
γ-Secretase
Online Access:http://link.springer.com/article/10.1186/s13195-017-0279-1

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http://link.springer.com/article/10.1186/s13195-017-0279-1

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