Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome.

Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome.

Cockayne syndrome (CS) is a photosensitive, DNA repair disorder associated with progeria that is caused by a defect in the transcription-coupled repair subpathway of nucleotide excision repair (NER). Here, complete inactivation of NER in Csb(m/m)/Xpa(-/-) mutants causes a phenotype that reliably mim...

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Bibliographic Details
Main Authors: Ingrid van der Pluijm, George A Garinis, Renata M C Brandt, Theo G M F Gorgels, Susan W Wijnhoven, Karin E M Diderich, Jan de Wit, James R Mitchell, Conny van Oostrom, Rudolf Beems, Laura J Niedernhofer, Susana Velasco, Errol C Friedberg, Kiyoji Tanaka, Harry van Steeg, Jan H J Hoeijmakers, Gijsbertus T J van der Horst
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1698505?pdf=render

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http://europepmc.org/articles/PMC1698505?pdf=render

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