Spilanthol Inhibits Inflammatory Transcription Factors and iNOS Expression in Macrophages and Exerts Anti-inflammatory Effects in Dermatitis and Pancreatitis

Spilanthol Inhibits Inflammatory Transcription Factors and iNOS Expression in Macrophages and Exerts Anti-inflammatory Effects in Dermatitis and Pancreatitis

Activated macrophages upregulate inducible nitric oxide synthase (iNOS) leading to the profuse production of nitric oxide (NO) and, eventually, tissue damage. Using macrophage NO production as a biochemical marker of inflammation, we tested different parts (flower, leaf, and stem) of the medicinal p...

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Bibliographic Details
Main Authors: Edina Bakondi, Salam Bhopen Singh, Zoltán Hajnády, Máté Nagy-Pénzes, Zsolt Regdon, Katalin Kovács, Csaba Hegedűs, Tamara Madácsy, József Maléth, Péter Hegyi, Máté Á. Demény, Tibor Nagy, Sándor Kéki, Éva Szabó, László Virág
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
dermatitis
pancreatitis
macrophage
nitric oxide
inducible nitric oxide synthase
spilanthol
NFκB
FOXO1
IRF
Online Access:https://www.mdpi.com/1422-0067/20/17/4308

Internet

https://www.mdpi.com/1422-0067/20/17/4308

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