Raloxifene inhibits adipose tissue inflammation and adipogenesis through Wnt regulation in ovariectomized rats and 3 T3-L1 cells

Raloxifene inhibits adipose tissue inflammation and adipogenesis through Wnt regulation in ovariectomized rats and 3 T3-L1 cells

Abstract Background Loss of ovarian function, as in menopause or after ovariectomy (OVX), is closely associated with obesity and white adipose tissue (WAT) inflammation. Estrogen replacement protects against postmenopausal obesity but increases the risks of carcinogenesis. In the present study, we i...

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Bibliographic Details
Main Authors: Hsin-Hsueh Shen, Chien-Yi Yang, Ching-Wen Kung, Shu-Ying Chen, Hong-Min Wu, Pao-Yun Cheng, Kwok-Keung Lam, Yen-Mei Lee
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Biomedical Science
Subjects:
Raloxifene
Menopause
Obesity
White adipose tissue
Inflammation
Wnt10b
Online Access:http://link.springer.com/article/10.1186/s12929-019-0556-3

Internet

http://link.springer.com/article/10.1186/s12929-019-0556-3

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