Circ-ACTR2 aggravates the high glucose-induced cell dysfunction of human renal mesangial cells through mediating the miR-205-5p/HMGA2 axis in diabetic nephropathy

Circ-ACTR2 aggravates the high glucose-induced cell dysfunction of human renal mesangial cells through mediating the miR-205-5p/HMGA2 axis in diabetic nephropathy

Abstract Background Circular RNAs (circRNAs) have been considered as pivotal biomarkers in Diabetic nephropathy (DN). CircRNA ARP2 actin-related protein 2 homolog (circ-ACTR2) could promote the HG-induced cell injury in DN. However, how circ-ACTR2 acts in DN is still unclear. This study aimed to exp...

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Bibliographic Details
Main Authors: Jie Yun, Jinyu Ren, Yufei Liu, Lijuan Dai, Liqun Song, Xiaopeng Ma, Shan Luo, Yexu Song
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Circ-ACTR2
Renal mesangial cells
Diabetic nephropathy
miR-205-5p
HMGA2
Online Access:https://doi.org/10.1186/s13098-021-00692-x

Internet

https://doi.org/10.1186/s13098-021-00692-x

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