Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis

Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis

12/15 lipoxygenase (12/15LO) oxidizes polyunsaturated fatty acids (PUFAs) to form bioactive lipid mediators. The role of 12/15LO in atherosclerosis development remains controversial. We evaluated atherosclerosis development and lipid metabolism in 12/15LO-LDL receptor (LDLr) double knockout (DK) vs....

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Bibliographic Details
Main Authors: Shunxing Rong, Qiang Cao, Mingxia Liu, Jeongmin Seo, Lin Jia, Elena Boudyguina, Abraham K. Gebre, Perry L. Colvin, Thomas L. Smith, Robert C. Murphy, Nilamadhab Mishra, John S. Parks
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Journal of Lipid Research
Subjects:
bone marrow transplantation
Kupffer cell
hepatosteatosis
VLDL metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520405620

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http://www.sciencedirect.com/science/article/pii/S0022227520405620

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