Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep).

Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep).

We previously designed a new family of artificial proteins named αRep based on a subgroup of thermostable helicoidal HEAT-like repeats. We have now assembled a large optimized αRep library. In this library, the side chains at each variable position are not fully randomized but instead encoded by a d...

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Bibliographic Details
Main Authors: Asma Guellouz, Marie Valerio-Lepiniec, Agathe Urvoas, Anne Chevrel, Marc Graille, Zaineb Fourati-Kammoun, Michel Desmadril, Herman van Tilbeurgh, Philippe Minard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3754942?pdf=render

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http://europepmc.org/articles/PMC3754942?pdf=render

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