Mitomycin-C Treatment Followed by Culture Produces Long-Term Survival of Islet Xenografts in a Rat-to Mouse Model

One of the goals of islet transplantation is to transplant viable islets without host immunosuppression. The present study was designed to determine whether pretreatment of islets with mitomycin-C (MMC) followed by culture enhances islet survival in a rat-to-mouse xenogeneic combination. WS(RT1k) ra...

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Bibliographic Details
Main Authors: Takashi Gunji, Takuro Saito, Yoshihiro Sato, Shinichi Matsuyama, Kazuya Ise, Takashi Kimura, Takayuki Anazawa, Mitsukazu Gotoh M.D.
Format: Article
Language:English
Published: SAGE Publishing 2008-06-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368908786092720