Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort
Diet may influence the development of inflammatory bowel disease through the modulation of inflammation. We investigated whether the inflammatory potential of the diet is associated with the risk of Crohn’s disease (CD) and ulcerative colitis (UC) in the Spanish cohort of the European Prospective In...
Main Authors: | , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-06-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6643/13/7/2201 |
id |
doaj-e0225d1276454463ac6566cb74991f1a |
---|---|
record_format |
Article |
spelling |
doaj-e0225d1276454463ac6566cb74991f1a2021-07-23T13:58:19ZengMDPI AGNutrients2072-66432021-06-01132201220110.3390/nu13072201Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain CohortMarcela Guevara0Elena Salamanca-Fernández1Estrella Miqueleiz2Diana Gavrila3Pilar Amiano4Catalina Bonet5Miguel Rodríguez-Barranco6José María Huerta7Luis Bujanda8María José Sánchez9María Dolores Chirlaque10Antonio Agudo11Eva Ardanaz12Jesús Castilla13Instituto de Salud Pública de Navarra, 31003 Pamplona, SpainInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012 Granada, SpainInstituto de Salud Pública de Navarra, 31003 Pamplona, SpainConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, SpainConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, SpainUnit of Nutrition and Cancer, Catalan Institute of Oncology—ICO, and Nutrition and Cancer Group, Epidemiology, Public Health, Cancer Prevention and Palliative Care Program, Bellvitge Biomedical Research Institute-IDIBELL, 08908 L’Hospitalet de Llobregat, SpainConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, SpainConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, SpainDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, 20014 San Sebastian, SpainConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, SpainConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, SpainUnit of Nutrition and Cancer, Catalan Institute of Oncology—ICO, and Nutrition and Cancer Group, Epidemiology, Public Health, Cancer Prevention and Palliative Care Program, Bellvitge Biomedical Research Institute-IDIBELL, 08908 L’Hospitalet de Llobregat, SpainInstituto de Salud Pública de Navarra, 31003 Pamplona, SpainInstituto de Salud Pública de Navarra, 31003 Pamplona, SpainDiet may influence the development of inflammatory bowel disease through the modulation of inflammation. We investigated whether the inflammatory potential of the diet is associated with the risk of Crohn’s disease (CD) and ulcerative colitis (UC) in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). The study included 32,633 participants aged 29–69 years. The inflammatory potential of the diet was measured by using an inflammatory score of the diet (ISD) based on a baseline dietary history questionnaire. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During 21 years (674,547 person-years) of follow-up, 32 and 57 participants developed CD and UC, respectively. In multivariable analysis, a one-standard deviation (SD) increment in the ISD (two-unit increase) was associated with a higher risk of CD (HR of 1.71; 95% CI: 1.05–2.80; <i>p</i> = 0.031). By contrast, ISD was not associated with UC (HR for one-SD increment of 0.89; 95% CI: 0.66–1.19; <i>p</i> = 0.436). Our results suggest that consuming a more pro-inflammatory diet may contribute to the risk of CD, supporting that a healthy diet might be beneficial in its prevention. Further, larger studies are needed to verify these findings.https://www.mdpi.com/2072-6643/13/7/2201Crohn’s diseaseulcerative colitisinflammatory bowel diseaseinflammatory potential of the dietinflammationprospective cohort study |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marcela Guevara Elena Salamanca-Fernández Estrella Miqueleiz Diana Gavrila Pilar Amiano Catalina Bonet Miguel Rodríguez-Barranco José María Huerta Luis Bujanda María José Sánchez María Dolores Chirlaque Antonio Agudo Eva Ardanaz Jesús Castilla |
spellingShingle |
Marcela Guevara Elena Salamanca-Fernández Estrella Miqueleiz Diana Gavrila Pilar Amiano Catalina Bonet Miguel Rodríguez-Barranco José María Huerta Luis Bujanda María José Sánchez María Dolores Chirlaque Antonio Agudo Eva Ardanaz Jesús Castilla Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort Nutrients Crohn’s disease ulcerative colitis inflammatory bowel disease inflammatory potential of the diet inflammation prospective cohort study |
author_facet |
Marcela Guevara Elena Salamanca-Fernández Estrella Miqueleiz Diana Gavrila Pilar Amiano Catalina Bonet Miguel Rodríguez-Barranco José María Huerta Luis Bujanda María José Sánchez María Dolores Chirlaque Antonio Agudo Eva Ardanaz Jesús Castilla |
author_sort |
Marcela Guevara |
title |
Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort |
title_short |
Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort |
title_full |
Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort |
title_fullStr |
Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort |
title_full_unstemmed |
Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort |
title_sort |
inflammatory potential of the diet and incidence of crohn’s disease and ulcerative colitis in the epic-spain cohort |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-06-01 |
description |
Diet may influence the development of inflammatory bowel disease through the modulation of inflammation. We investigated whether the inflammatory potential of the diet is associated with the risk of Crohn’s disease (CD) and ulcerative colitis (UC) in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). The study included 32,633 participants aged 29–69 years. The inflammatory potential of the diet was measured by using an inflammatory score of the diet (ISD) based on a baseline dietary history questionnaire. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During 21 years (674,547 person-years) of follow-up, 32 and 57 participants developed CD and UC, respectively. In multivariable analysis, a one-standard deviation (SD) increment in the ISD (two-unit increase) was associated with a higher risk of CD (HR of 1.71; 95% CI: 1.05–2.80; <i>p</i> = 0.031). By contrast, ISD was not associated with UC (HR for one-SD increment of 0.89; 95% CI: 0.66–1.19; <i>p</i> = 0.436). Our results suggest that consuming a more pro-inflammatory diet may contribute to the risk of CD, supporting that a healthy diet might be beneficial in its prevention. Further, larger studies are needed to verify these findings. |
topic |
Crohn’s disease ulcerative colitis inflammatory bowel disease inflammatory potential of the diet inflammation prospective cohort study |
url |
https://www.mdpi.com/2072-6643/13/7/2201 |
work_keys_str_mv |
AT marcelaguevara inflammatorypotentialofthedietandincidenceofcrohnsdiseaseandulcerativecolitisintheepicspaincohort AT elenasalamancafernandez inflammatorypotentialofthedietandincidenceofcrohnsdiseaseandulcerativecolitisintheepicspaincohort AT estrellamiqueleiz inflammatorypotentialofthedietandincidenceofcrohnsdiseaseandulcerativecolitisintheepicspaincohort AT dianagavrila inflammatorypotentialofthedietandincidenceofcrohnsdiseaseandulcerativecolitisintheepicspaincohort AT pilaramiano inflammatorypotentialofthedietandincidenceofcrohnsdiseaseandulcerativecolitisintheepicspaincohort AT catalinabonet inflammatorypotentialofthedietandincidenceofcrohnsdiseaseandulcerativecolitisintheepicspaincohort AT miguelrodriguezbarranco inflammatorypotentialofthedietandincidenceofcrohnsdiseaseandulcerativecolitisintheepicspaincohort AT josemariahuerta inflammatorypotentialofthedietandincidenceofcrohnsdiseaseandulcerativecolitisintheepicspaincohort AT luisbujanda inflammatorypotentialofthedietandincidenceofcrohnsdiseaseandulcerativecolitisintheepicspaincohort AT mariajosesanchez inflammatorypotentialofthedietandincidenceofcrohnsdiseaseandulcerativecolitisintheepicspaincohort AT mariadoloreschirlaque inflammatorypotentialofthedietandincidenceofcrohnsdiseaseandulcerativecolitisintheepicspaincohort AT antonioagudo inflammatorypotentialofthedietandincidenceofcrohnsdiseaseandulcerativecolitisintheepicspaincohort AT evaardanaz inflammatorypotentialofthedietandincidenceofcrohnsdiseaseandulcerativecolitisintheepicspaincohort AT jesuscastilla inflammatorypotentialofthedietandincidenceofcrohnsdiseaseandulcerativecolitisintheepicspaincohort |
_version_ |
1721286716321431552 |