Neuroinvasiveness of the MR766 strain of Zika virus in IFNAR-/- mice maps to prM residues conserved amongst African genotype viruses.

Neuroinvasiveness of the MR766 strain of Zika virus in IFNAR-/- mice maps to prM residues conserved amongst African genotype viruses.

Zika virus (ZIKV) strains are classified into the African and Asian genotypes. The higher virulence of the African MR766 strain, which has been used extensively in ZIKV research, in adult IFNα/β receptor knockout (IFNAR-/-) mice is widely viewed as an artifact associated with mouse adaptation due to...

Full description

Bibliographic Details
Main Authors: Eri Nakayama, Fumihiro Kato, Shigeru Tajima, Shinya Ogawa, Kexin Yan, Kenta Takahashi, Yuko Sato, Tadaki Suzuki, Yasuhiro Kawai, Takuya Inagaki, Satoshi Taniguchi, Thuy T Le, Bing Tang, Natalie A Prow, Akihiko Uda, Takahiro Maeki, Chang-Kweng Lim, Alexander A Khromykh, Andreas Suhrbier, Masayuki Saijo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009788

Internet

https://doi.org/10.1371/journal.ppat.1009788

Similar Items