Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib

Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib

Gefitinib resistance in triple negative breast cancer (TNBC) is a growing important concern. Glutathione peroxidase 4 (GPX4) is a main regulator of ferroptosis, which is pivotal for TNBC cell growth. We investigated GPX4-mediated ferroptosis in gefitinib sensitivity in TNBC. Gefitinib resistant TNBC...

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Bibliographic Details
Main Authors: Xiang Song, Xinzhao Wang, Zhaoyun Liu, Zhiyong Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
triple negative breast cancer
gefitinib
GPX4
ferroptosis
sensitivity
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.597434/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.597434/full

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