Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1

Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1

Leukocyte migration, a hallmark of the inflammatory response, is stimulated by the interactions between chemokines, which are expressed in injured or infected tissues, and chemokine receptors, which are G protein-coupled receptors (GPCRs) expressed in the leukocyte plasma membrane. One mechanism for...

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Bibliographic Details
Main Authors: Julie Sanchez, J. Robert Lane, Meritxell Canals, Martin J. Stone
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
chemokine
chemokine receptor
chemokine receptor 1 (CCR1)
G protein-coupled receptor (GPCR)
binding
receptor activation
biased agonism
Online Access:https://www.mdpi.com/1422-0067/20/10/2417

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https://www.mdpi.com/1422-0067/20/10/2417

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