Effects of Decreased Vitamin D and Accumulated Uremic Toxin on Human CYP3A4 Activity in Patients with End-Stage Renal Disease

Effects of Decreased Vitamin D and Accumulated Uremic Toxin on Human CYP3A4 Activity in Patients with End-Stage Renal Disease

In patients with end-stage renal disease, not only renal clearance but also hepatic clearance is known to be impaired. For instance, the concentration of erythromycin, a substrate of cytochrome P450 3A4 (CYP3A4), has been reported to be elevated in patients with end-stage renal disease. The purpose...

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Bibliographic Details
Main Authors: Kohshi Nishiguchi, Taku Furukubo, Satoshi Izumi, Tomoyuki Yamakawa, Tetsuya Minegaki, Shima Hiraoka, Asuka Shiraishi, Ayaka Miyoshi, Satomi Hosoda, Yui Nagano, Masayuki Tsujimoto
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Toxins
Subjects:
CYP3A4
1,25-dihydroxyvitamin D
uremic toxins
end-stage renal disease
vitamin D receptor (VDR)
Online Access:http://www.mdpi.com/2072-6651/5/8/1475

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http://www.mdpi.com/2072-6651/5/8/1475

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