Shear stress activates ATOH8 via autocrine VEGF promoting glycolysis dependent-survival of colorectal cancer cells in the circulation

Shear stress activates ATOH8 via autocrine VEGF promoting glycolysis dependent-survival of colorectal cancer cells in the circulation

Abstract Background Metastasis and recurrence, wherein circulating tumour cells (CTCs) play an important role, are the leading causes of death in colorectal cancer (CRC). Metastasis-initiating CTCs manage to maintain intravascular survival under anoikis, immune attack, and importantly shear stress;...

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Bibliographic Details
Main Authors: Qiong Huang, Shaowei Li, Xingbin Hu, Mengting Sun, Qijing Wu, Huiru Dai, Yujing Tan, Fei Sun, Chunlin Wang, Xiaoxiang Rong, Wangjun Liao, Jianjun Peng, Jianjun Xiao, Li Huang, Jiao Wang, Bishan Liang, Kelin Lin, Yajing Liu, Min Shi
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Laminar shear stress
Colorectal cancer
ATOH8
Glycolysis
VEGF
Online Access:https://doi.org/10.1186/s13046-020-1533-0

Internet

https://doi.org/10.1186/s13046-020-1533-0

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