Human IgA-Expressing Bone Marrow Plasma Cells Characteristically Upregulate Programmed Cell Death Protein-1 Upon B Cell Receptor Stimulation

Human IgA-Expressing Bone Marrow Plasma Cells Characteristically Upregulate Programmed Cell Death Protein-1 Upon B Cell Receptor Stimulation

The functions of bone marrow plasma cells (BMPC) beyond antibody production are not fully elucidated and distinct subsets of BMPC suggest potential different functions. Phenotypic differences were identified for human BMPC depending on CD19 expression. Since CD19 is a co-stimulatory molecule of the...

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Bibliographic Details
Main Authors: Annika Wiedemann, Marie Lettau, Ina Wirries, Annemarie Jungmann, Abdulrahman Salhab, Gilles Gasparoni, Henrik E. Mei, Carsten Perka, Jörn Walter, Andreas Radbruch, Andreia C. Lino, Thomas Dörner
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
plasma cells
B cell receptor
signaling
human bone marrow
B cells
CD19
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.628923/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.628923/full

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