Asymmetric total synthesis of smyrindiol employing an organocatalytic aldol key step

The first organocatalytic asymmetric synthesis of smyrindiol, by using an (S)-proline catalyzed enantioselective intramolecular aldol reaction as the key step, is described. Smyrindiol was synthesized from commercially available 2,4-dihydroxybenzaldehyde in 15 steps, with excellent stereoselectivity...

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Bibliographic Details
Main Authors: Dieter Enders, Jeanne Fronert, Tom Bisschops, Florian Boeck
Format: Article
Language:English
Published: Beilstein-Institut 2012-07-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.8.123