Protective Role of a <em>TMPRSS2</em> Variant on Severe COVID-19 Outcome in Young Males and Elderly Women

Protective Role of a <em>TMPRSS2</em> Variant on Severe COVID-19 Outcome in Young Males and Elderly Women

The protease encoded by the <i>TMPRSS2</i> gene facilitates viral infections and has been implicated in the pathogenesis of SARS-CoV-2. We analyzed the <i>TMPRSS2</i> sequence and correlated the protein variants with the clinical features of a cohort of 1177 patients affected...

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Bibliographic Details
Main Authors: Maria Monticelli, Bruno Hay Mele, Elisa Benetti, Chiara Fallerini, Margherita Baldassarri, Simone Furini, Elisa Frullanti, Francesca Mari, GEN-COVID Multicenter Study, Giuseppina Andreotti, Maria Vittoria Cubellis, Alessandra Renieri
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Genes
Subjects:
COVID-19
TMPRSS2
V197M
missense mutation
Whole-Exome Sequencing (WES)
Online Access:https://www.mdpi.com/2073-4425/12/4/596

Internet

https://www.mdpi.com/2073-4425/12/4/596

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