Conjugate-SELEX: A High-throughput Screening of Thioaptamer-liposomal Nanoparticle Conjugates for Targeted Intracellular Delivery of Anticancer Drugs

Conjugate-SELEX: A High-throughput Screening of Thioaptamer-liposomal Nanoparticle Conjugates for Targeted Intracellular Delivery of Anticancer Drugs

Patients with advanced head and neck squamous cell carcinoma receiving chemotherapy have a poor prognosis partly due to normal tissue toxicity; therefore, development of a tumor-targeted drug delivery platform to minimize collateral toxicity is a goal of cancer nanomedicine. Aptamers can achieve thi...

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Bibliographic Details
Main Authors: Qingshan Mu, Akshaya Annapragada, Mayank Srivastava, Xin Li, Jean Wu, Varatharasa Thiviyanathan, Hongyu Wang, Alexander Williams, David Gorenstein, Ananth Annapragada, Nadarajah Vigneswaran
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
AHNAK
aptamers
conjugate-SELEX
head and neck squamous cell carcinoma
ligand-targeted drug delivery
nanoparticle
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117301002

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http://www.sciencedirect.com/science/article/pii/S2162253117301002

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