High-resolution AFM structure of DNA G-wires in aqueous solution

DNA and RNA G-quadruplexes can stack to form higher-order structures called G-wires. Here the authors report high-resolution AFM images of higher-order DNA G-quadruplexes in aqueous solution that could impact the design of G-wire based nanodevices and the understanding of G-wires in biology.

Bibliographic Details
Main Authors: Krishnashish Bose, Christopher J. Lech, Brahim Heddi, Anh Tuân Phan
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04016-y