A single intravenous AAV9 injection mediates bilateral gene transfer to the adult mouse retina.

A single intravenous AAV9 injection mediates bilateral gene transfer to the adult mouse retina.

Widespread gene delivery to the retina is an important challenge for the treatment of retinal diseases, such as retinal dystrophies. We and others have recently shown that the intravenous injection of a self-complementary (sc) AAV9 vector can direct efficient cell transduction in the central nervous...

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Bibliographic Details
Main Authors: Alexis-Pierre Bemelmans, Sandra Duqué, Christel Rivière, Stéphanie Astord, Mélissa Desrosiers, Thibault Marais, José-Alain Sahel, Thomas Voit, Martine Barkats
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3626698?pdf=render

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http://europepmc.org/articles/PMC3626698?pdf=render

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