SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease

SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease

Post-translational modification pathways such as SUMOylation are integral to all cellular processes and tissue homeostasis. We investigated the possible involvement of SUMOylation in the epithelial signalling in Crohn's disease (CD) and ulcerative colitis (UC), the two major forms of inflammato...

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Bibliographic Details
Main Authors: Salman Ahmad Mustfa, Mukesh Singh, Aamir Suhail, Gayatree Mohapatra, Smriti Verma, Debangana Chakravorty, Sarika Rana, Ritika Rampal, Atika Dhar, Sudipto Saha, Vineet Ahuja, C. V. Srikanth
Format: Article
Language:English
Published: The Royal Society 2017-01-01
Series:Open Biology
Subjects:
colitis
inflammation
post-translational modification
sumoylation
epithelial signalling
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170024

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170024

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