Enhanced Amikacin Diffusion With Ultrasound and Microbubbles in a Mechanically Ventilated Condensed Lung Rabbit Model

Enhanced Amikacin Diffusion With Ultrasound and Microbubbles in a Mechanically Ventilated Condensed Lung Rabbit Model

The poor diffusion of intravenous antibiotics in lung tissue makes nosocomial pneumonia challenging to treat, notably in critical patients under mechanical ventilation. The combination of ultrasound and microbubbles (USMB) is an emerging method for non-invasive and targeted enhancement of uptake of...

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Bibliographic Details
Main Authors: Fabien Espitalier, François Darrouzain, Jean-Michel Escoffre, David Ternant, Eric Piver, Ayache Bouakaz, Francis Remerand
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
sonoporation
ultrasound
microbubbles
antibiotic therapy
lung
amikacin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01562/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01562/full

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