Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models

Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models

We explored whether the combination of lurbinectedin (PM01183) with the antimetabolite gemcitabine could result in a synergistic antitumor effect in pancreatic ductal adenocarcinoma (PDA) mouse models. We also studied the contribution of lurbinectedin to this synergism. This drug presents a dual pha...

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Bibliographic Details
Main Authors: María Virtudes Céspedes, María José Guillén, Pedro Pablo López-Casas, Francesca Sarno, Alberto Gallardo, Patricia Álamo, Carmen Cuevas, Manuel Hidalgo, Carlos María Galmarini, Paola Allavena, Pablo Avilés, Ramón Mangues
Format: Article
Language:English
Published: The Company of Biologists 2016-12-01
Series:Disease Models & Mechanisms
Subjects:
PDA mouse models
Lurbinectedin
Gemcitabine
Synergism
Tumor-associated macrophage depletion
Online Access:http://dmm.biologists.org/content/9/12/1461

Internet

http://dmm.biologists.org/content/9/12/1461

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