Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

We use a genome-wide association of 1 million parental lifespans of genotyped subjects and data on mortality risk factors to validate previously unreplicated findings near CDKN2B-AS1, ATXN2/BRAP, FURIN/FES, ZW10, PSORS1C3, and 13q21.31, and identify and replicate novel findings near ABO, ZC3HC1, and...

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Bibliographic Details
Main Authors: Paul RHJ Timmers, Ninon Mounier, Kristi Lall, Krista Fischer, Zheng Ning, Xiao Feng, Andrew D Bretherick, David W Clark, eQTLGen Consortium, Xia Shen, Tõnu Esko, Zoltán Kutalik, James F Wilson, Peter K Joshi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
genomics
longevity
lifespan
complex trait
Online Access:https://elifesciences.org/articles/39856

Internet

https://elifesciences.org/articles/39856

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