High Temperature Drives Topoisomerase Mediated Chromosomal Break Repair Pathway Choice

High Temperature Drives Topoisomerase Mediated Chromosomal Break Repair Pathway Choice

Cancer-causing mutations often arise from inappropriate DNA repair, yet acute exposure to DNA damage is widely used to treat cancer. The challenge remains in how to specifically induce excessive DNA damage in cancer cells while minimizing the undesirable effects of genomic instability in noncancerou...

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Bibliographic Details
Main Authors: Mohamed E. Ashour, Walaa Allam, Waheba Elsayed, Reham Atteya, Menattallah Elserafy, Sameh Magdeldin, Mohamed K. Hassan, Sherif F. El-Khamisy
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
topoisomerase
TDP1
TDP2
cancer
ageing
hyperthermia
Online Access:https://www.mdpi.com/2072-6694/13/10/2315

Internet

https://www.mdpi.com/2072-6694/13/10/2315

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