Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesis

Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesis

Abstract Background Overexpression and nuclear enrichment of the oncogene yes-associated protein (YAP) cause tumor initiation and support tumor progression in human hepatocellular carcinoma (HCC) via cell autonomous mechanisms. However, how YAP expression in tumor cells affects intercellular communi...

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Bibliographic Details
Main Authors: Simone Marquard, Stefan Thomann, Sofia M. E. Weiler, Michaela Bissinger, Teresa Lutz, Carsten Sticht, Marcell Tóth, Carolina de la Torre, Norbert Gretz, Beate K. Straub, Jens Marquardt, Peter Schirmacher, Kai Breuhahn
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Cell Communication and Signaling
Subjects:
Hippo pathway
Liver cancer
Hepatocellular carcinoma
Transcriptional regulator
Oncogene
Online Access:http://link.springer.com/article/10.1186/s12964-020-00634-6

Internet

http://link.springer.com/article/10.1186/s12964-020-00634-6

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