RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system.

RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system.

ATP-dependent paracrine signaling, mediated via the release of ATP through plasma membrane-embedded hemichannels of the connexin family, coordinates a synchronized response between neighboring cells. Connexin 43 (Cx43) hemichannels that are present in the plasma membrane need to be tightly regulated...

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Bibliographic Details
Main Authors: Raf Ponsaerts, Catheleyne D'hondt, Fréderic Hertens, Jan B Parys, Luc Leybaert, Johan Vereecke, Bernard Himpens, Geert Bultynck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22860057/?tool=EBI

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