KDM6A Lysine Demethylase Directs Epigenetic Polarity of MDSCs during Murine Sepsis

KDM6A Lysine Demethylase Directs Epigenetic Polarity of MDSCs during Murine Sepsis

Sepsis-induced myeloid-derived suppressor cells (MDSCs) increase mortality risk. We previously identified that long non-coding RNA Hotairm1 supports myeloid precursor shifts to Gr1+CD11b+ MDSCs during mouse sepsis. A major unanswered question is what molecular processes control Hotairm1 expression....

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Bibliographic Details
Main Authors: Isatou Bah, Tuqa Alkhateeb, Dima Youssef, Zhi Q. Yao, Charles E. McCall, Mohamed El Gazzar
Format: Article
Language:English
Published: Karger Publishers 2021-07-01
Series:Journal of Innate Immunity
Subjects:
sepsis
myeloid-derived suppressor cell
immune suppression
hotairm1
epigenetics
Online Access:https://www.karger.com/Article/FullText/517407

Internet

https://www.karger.com/Article/FullText/517407

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