Acitretin mitigates uroporphyrin-induced bone defects in congenital erythropoietic porphyria models

Acitretin mitigates uroporphyrin-induced bone defects in congenital erythropoietic porphyria models

Abstract Congenital erythropoietic porphyria (CEP) is a rare genetic disorder leading to accumulation of uro/coproporphyrin-I in tissues due to inhibition of uroporphyrinogen-III synthase. Clinical manifestations of CEP include bone fragility, severe photosensitivity and photomutilation. Currently t...

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Bibliographic Details
Main Authors: Juliana Bragazzi Cunha, Jared S. Elenbaas, Dhiman Maitra, Ning Kuo, Rodrigo Azuero-Dajud, Allison C. Ferguson, Megan S. Griffin, Stephen I. Lentz, Jordan A. Shavit, M. Bishr Omary
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88668-9

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https://doi.org/10.1038/s41598-021-88668-9

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