<span style="font-variant: small-caps">A H2AX–CARP-1 </span>Interaction Regulates Apoptosis Signaling Following DNA Damage

<span style="font-variant: small-caps">A H2AX–CARP-1 </span>Interaction Regulates Apoptosis Signaling Following DNA Damage

Cell Cycle and Apoptosis Regulatory Protein (CARP-1/CCAR1) is a peri-nuclear phosphoprotein that regulates apoptosis via chemotherapeutic Adriamycin (doxorubicin) and a novel class of CARP-1 functional mimetic (CFM) compounds. Although Adriamycin causes DNA damage, data from Comet assays revealed th...

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Bibliographic Details
Main Authors: Sreeja C. Sekhar, Jaganathan Venkatesh, Vino T. Cheriyan, Magesh Muthu, Edi Levi, Hadeel Assad, Paul Meister, Vishnu V. Undyala, James W. Gauld, Arun K. Rishi
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cancers
Subjects:
CCAR1/CARP-1
γH2AX
apoptosis
chemotherapeutics
cancer cells
Online Access:https://www.mdpi.com/2072-6694/11/2/221

Internet

https://www.mdpi.com/2072-6694/11/2/221

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