Selective Interleukin-6 Trans-Signaling Blockade Is More Effective Than Panantagonism in Reperfused Myocardial Infarction

Selective Interleukin-6 Trans-Signaling Blockade Is More Effective Than Panantagonism in Reperfused Myocardial Infarction

Summary: Interleukin (IL)-6 is an emerging therapeutic target in myocardial infarction (MI). IL-6 has 2 distinct signaling pathways: trans-signaling, which mediates inflammation, and classic signaling, which also has anti-inflammatory effects. The novel recombinant fusion protein sgp130Fc achieves e...

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Bibliographic Details
Main Authors: Marc Jonathan George, MB ChB, PhD, Nur Hayati Jasmin, BSc, MRes, Valerie Taylor Cummings, Angela Richard-Loendt, BSc, MSc, Francesca Launchbury, BSc, Kevin Woollard, PhD, Tabitha Turner-Stokes, MB BChir, Ana Isabel Garcia Diaz, BSc, Mark Lythgoe, PhD, Daniel James Stuckey, BSc, DPhil, Aroon Dinesh Hingorani, MB BS, PhD, Derek William Gilroy, PhD
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:JACC: Basic to Translational Science
Subjects:
inflammation
interleukin-6
myocardial infarction
reperfusion
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X21000681

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http://www.sciencedirect.com/science/article/pii/S2452302X21000681

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