Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms

Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms

The cardiac ventricular action potential depends on several voltage-gated ion channels, including NaV, CaV, and KV channels. Mutations in these channels can cause Long QT Syndrome (LQTS) which increases the risk for ventricular fibrillation and sudden cardiac death. Polyunsaturated fatty acids (PUFA...

Full description

Bibliographic Details
Main Authors: Briana M Bohannon, Alicia de la Cruz, Xiaoan Wu, Jessica J Jowais, Marta E Perez, Derek M Dykxhoorn, Sara I Liin, H Peter Larsson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
Xenopus oocytes
iks
Cav1.2
Nav1.5
Long QT Syndrome
polyunsaturated fatty acids
Online Access:https://elifesciences.org/articles/51453

Internet

https://elifesciences.org/articles/51453

Similar Items