In vitro and in vivo characterization of anti-malarial acylphenoxazine derivatives prepared from basic blue 3

In vitro and in vivo characterization of anti-malarial acylphenoxazine derivatives prepared from basic blue 3

Abstract Background Basic blue 3 is a promising anti-malarial lead compound based on the π-delocalized lipophilic cation hypothesis. Its derivatives with nitrogen atoms bonded to carbon atoms at the 3- and 7-positions on the phenoxazine ring were previously shown to exert potent antiprotozoal activi...

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Main Authors: Takahiro Tougan, Kazunori Takahashi, Mayumi Ikegami-Kawai, Masako Horiuchi, Shiho Mori, Maiko Hosoi, Toshihiro Horii, Masataka Ihara, Masayoshi Tsubuki
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Malaria Journal
Subjects:
Basic blue 3
ITT derivatives
Anti-malarial activity
Cytotoxicity
π-Delocalized lipophilic cations
DLC hypothesis
Online Access:http://link.springer.com/article/10.1186/s12936-019-2873-0

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http://link.springer.com/article/10.1186/s12936-019-2873-0

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