Single-Cell Transcriptomics of Glioblastoma Reveals a Unique Tumor Microenvironment and Potential Immunotherapeutic Target Against Tumor-Associated Macrophage

Single-Cell Transcriptomics of Glioblastoma Reveals a Unique Tumor Microenvironment and Potential Immunotherapeutic Target Against Tumor-Associated Macrophage

BackgroundThe main immune cells in GBM are tumor-associated macrophages (TAMs). Thus far, the studies investigating the activation status of TAM in GBM are mainly limited to bulk RNA analyses of individual tumor biopsies. The activation states and transcriptional signatures of TAMs in GBM remain poo...

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Bibliographic Details
Main Authors: Xiaoteng Cui, Qixue Wang, Junhu Zhou, Yunfei Wang, Can Xu, Fei Tong, Hongjun Wang, Chunsheng Kang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
immune landscape
glioblastoma
single-cell RNA sequencing
macrophage polarization
SPI1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.710695/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.710695/full

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