Exposure of the cytoplasm to low-dose X-rays modifies ataxia telangiectasia mutated-mediated DNA damage responses

Abstract We recently showed that when a low X-ray dose is used, cell death is enhanced in nucleus-irradiated compared with whole-cell-irradiated cells; however, the role of the cytoplasm remains unclear. Here, we show changes in the DNA damage responses with or without X-ray microbeam irradiation of...

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Bibliographic Details
Main Authors: Munetoshi Maeda, Masanori Tomita, Mika Maeda, Hideki Matsumoto, Noriko Usami, Kyo Kume, Katsumi Kobayashi
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-92213-z